1920

• On April 12 Vierne returns to Paris almost financially ruined, a physically and psychologically broken man. He suffers from acute neuritis in his right arm, rendering it useless. He finds the organ at Notre-Dame-de-Paris in alarming condition. In the short time of his absence since the end of the War, all new faces have arisen on the Paris musical scene. He must nonetheless reëstablish his career. Through a fortuituous encounter, it is Madeleine Richepin who will assist him in making a shining return.

1921

• Trimphal March for the Centennary of Napoleon

1923-24

• Fifth Symphony.

1925

• Concert tour of Ireland and Scotland as a fundraising project toward restoration of the organ.

1926

• Pièce symphonique (an orchestral adaptation of material from his first three organ symphonies).
• Poème, for piano and orchestra.

1926-27

• Twenty-four Fantasy Pieces in 4 books, for organ.

1927

• January 19, Vierne leaves for a four-month concert tour of the United States and Canada. He will play for a total of 70,000 people. His programs include many of his own works, including the newly-composed 24 Fantasy Pieces. He wins universal critical acclaim.

1928

• Evenings Abroad for 'cello and piano'.
• Vierne records his Three Improvisations on 78 RPM disc.

1929-31

• Vierne writes the Triptych. From time to time the Triptych is mistakenly considered to contain the three improvisations that were recorded on vinyl in 1929, but this is not the case. Those three improvisations have been written down later by Maurice Duruflé.

1930

• Vierne retreats to sunny Provence on holiday.
• Sixth Symphony et Les Angélus, for voice and organ or orchestra.

1931

• Ballade du désespéré, for tenor and piano (or orchestra).

1932

• The restoration of the organ of ND is completed at a total cost of 270.000 French francs.

1934

• Low Mass for the Dead.

1937

• Death of Widor.
• During his 1750th recital at Notre-Dame-de-Paris, Vierne suffers a sudden major stroke, and dies at his keyboard, in the organ loft, in the presence of his closest student Maurice Duruflé, with whom he is sharing that evening's program. The last piece played by Vierne is the "Stèle pour un enfant défunt", which was played that evening for the very first time.