1906

• Sonate pour violon et piano
• May 18: While walking one rainy night amid construction in the streets of Paris, Vierne suffers a serious fall, in which he breaks his right leg and ankle. This accident nearly costs him his career. He barely avoids amputation, but it will take a painful recovery lasting till December for him to recover from this setback and resume playing the organ.

1907

• January 6 - birth of a daughter, Colette (later Mrs Claude Lafontaine)
• At the Paris Conservatory, young Marcel Dupré takes first prize in Organ.

1907-08

• Symphony in A minor, for orchestra, which will not have its première until January 26, 1919, in Paris.

1909

• August 4 Vierne divorces his wife on account of her infidelity with Charles Mutin, the famous organbuilder and his supposed friend. Vierne is profoundly shattered and grieved by this treachery. Vierne receives custody of his eldest child Jacques [James], while his wife is granted custody of the younger children André [Andrew] and Colette solely by reason of their tender age. The marriage is annulled by the Catholic church only on condition that Vierne shall not remarry.
• His young son André contracts tuberculosis.

1910

• Sonata for violoncello and piano
• March 12, Vierne, now divorced six months, moves with his son into the home of his mother, who helps greatly with the upbringing of her grandson.
• The year of flooding, when the Seine floods the presbytery courtyard and the crypt of Notre-Dame Cathedral. The organ suffers much from the extremely humid, water-laden air, which causes extensive warping and mechanical damage to the instrument. In addition, the heating system installed only a few years earlier, in 1902, which used to heat the church so wonderfully and might have provided some dryness for the organ to stabilise, is totally destroyed.
• December 11, Vierne's mother suffers kidney failure.

1911

• At the end of January, Guilmant gives up his organ class at the Conservatory, placing his friend Vierne in charge.
• March 25, Vierne's mother dies of uremia, "after 83 days of the most dreadful agony a person ever witnessed." She is buried in the Montparnasse Cemetary.
• Guilmant, likewise stricken with uremia during February, succombs on March 29. Vierne will later write: "For me, this was a second cruel sorrow. I shared with this excellent man a friendship which never once in its 15 years saw a cloudy sky."
• After 18 years of distinguished and unpaid volunteer service as an assistant professor of organ at the Paris Conservatory, Vierne, on account of a sudden rift between Gabriel Fauré, director of the Conservatory, and Vierne's mentor Charles Widor (who has made an indiscrete remark about Fauré), is passed up for the post left vacant by the death of Guilmant. Longtime friend of Fauré and exceptional improvisationalist, Eugène Gigout, is appointed to the post. Vierne takes up a teaching position at the Schola Cantorum.
• A torrid summer follows the flooding of winter/spring 1910-11, the temperature reaching 72oC [162oF] beneath the rose of the organ. with disastrous consequences for the grand instrument: the wind chests start coming apart; the bellows suffer damage and the organ is mechanically thrown out of alignment throughout. Complete repair of the instrument will have to wait until 1932.
• Vierne composes his Third Symphony.

1912

• Low Mass, for organ or harmonium

1913

• Ravaged by tuberculosis, his son André dies on September 7 à Juziers.
• Twenty-year-old Lili Boulanger becomes the first woman to win the Prix de Rome.

1914

• January 3, his good friend, pianist Raoul Pugno dies in Moscow while on a concert tour.
• Start of the First World War in Europe.
• For the summer Vierne spends the holidays quietly in La Rochelle at the family home of his student Marthe Bracquemond. There, he composes the first six of his Twelve preludes for piano.
• He composes Psyché, for voice and orchestra and his Fourth Symphony.
• Vierne completes his 24 Pieces in free style, on which he has been at work since 1912.

1915

• Vierne senses the early stage of the glaucoma which now threatens to deprive him of all sight. He consults the Swiss ophthamologist, Professor Eperon.
• Jeanne Montjovet leaves him after a five-year relationship.

1916

• René Vierne, the composer's brother, is killed in combat, as are several of his other former students.
• July 12, Vierne leaves Paris for Switzerland, where he is the invited guest of the Countess du Boisrouvray and her family at the Villa Rochemont for the entire summer, during which time his glaucoma is treated in Lausanne. For each of the Countess' five children he composes a piece, comprising the collection Silhouettes d'enfants for piano. His stay in Switzerland, and later in Savoie, will continue through 1920.

1917

• The Cathedral of Notre-Dame-de-Paris undergoes an enemy bombardment during the War and suffers minor damage.
• News arrives of the death of his teenage son, Jacques - killed in combat on November 11. He composes his Quintet, for piano and strings.

1918

• October 9, Vierne undergoes an operation for secondary cataracts in his right eye, which is followed by a complication (scylites) requiring him to remain six months in a totally darkened room. The operation is not a success.

1919

• Les djinns, symphonic poem, on the famous poem by Victor Hugo.